Rangaramanujam M. Kannan
Associate Professor Chemical Eng. and Mat. Sci., Biomed. Eng.
B.E. (Hons.)
Birla Institute of Technology and Science, 1987
Ph.D.
California Institute of Technology, 1994
Postdoc.
University of Minnesota, 1994-1995
Fellow of the American Academy of Nanomedicine (August 2006)
Chief Technical Officer, nanoScience Engineering Corp., (7/2006- to date)
Member, Karmanos Cancer Institute
Ad hoc Member, National Cancer Institute Special Emphasis Study Section
NSF CAREER Award (1999)
Unilever Award for outstanding Ph.D. thesis in Polymer Science by ACS (1995)
Curriculum Vitae: pdf
Dendrimer Nanomedicine
Dendrimers are tree-like polymers (~5-10 nm) with a well-defined branching architecture that offer a new length scale for multifunctional delivery systems, with an ability to deliver therapeutics in a targeted manner, with simultaneous imaging. Our drug delivery group seeks to maximize the unique surface, cellular and in vivo properties of dendrimers for improved therapeutic efficacy. We do this through synthesis, in vitro and in vivo characterization of custom-designed dendrimer-based multifunctional nanodevices for cancer, inflammation (neuro and lung), and eye diseases. Translational research is enabled through inter-disciplinary collaborations with various components of the Wayne State Medical School.
Supercritical CO2-dispersed polymer nanocomposites
Achieving clay dispersion and improving polymer-clay interactions are key to producing superior nanocomposites. Using a patented, licensed technology based on the unique properties of supercritical carbon dioxide [discovered by Wayne State (Gulari, Manke, Kannan), and Ford researchers], we are preparing dispersed nanoclays and polymer clay nanocomposites. Current research focuses on improving processing times, and diversification of the scCO2 processing to a wide variety of commercial polymers. Scattering, rheology, and mechanical and rheo-optical techniques play a key role in understanding the dispersed nanocomposite properties.
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Drug release mechanisms and kinetics from dendrimer-drug conjugates with glutathione sensitive linkers.', Y. Kurtoglu, R. Navath, B. Wang, R. Romero, S. Kannan, RM Kannan*. Submitted to Biomaterials (September 2008).
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Dendrimer-drug conjugates for tailored intracellular drug release based on glutathione levels.', Navath, R; Y. Kurtoglu; B. Wang; S. Kannan;R. Romero; R.M. Kannan*. Bioconjugate Chemistry (October, 2008).
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Supercritical Carbon Dioxide-Processed Dispersed Polystyrene-Clay Nanocomposites.', Manitiu, Mihai; Bellair, Robert J.; Horsch, Steven; Gulari, Esin; Kannan, Rangaramanujam M. Macromolecules (In Press).
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The effect of surface functionality on cellular trafficking of dendrimers.', Perumal, Omathanu P.; Inapagolla, Rajyalakshmi; Kannan, Sujatha; Kannan, Rangaramanujam M. Biomaterials (2008), 29(24-25), 3469-3476.
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Engineering Strength, Porosity, and Emission Intensity of Nanostructured CdSe Networks by Altering the Building-Block Shape.', Yu, Hongtao; Bellair, Robert; Kannan, Rangaramanujam M.; Brock, Stephanie L. Journal of the American Chemical Society (2008), 130(15), 5054-5055
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Synthesis, characterization and in vitro release of dendrimer-streptokinase conjugates', X. Wang, R. Inapagolla, M. Lieh-Lai, R. M. Kannan, S. Kannan, Bioconjugate Chem.(2007), 18(3), 791-799
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Supercritical CO2 dispersion of nano-clays and clay/polymer nanocomposites', S. Horsch, G. Serhatkulu, E. Gulari, R. M. Kannan, Polymer 47 (21) 7485-7496 Oct 4 2006
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Activity of dendrimer-methotrexate conjugates in sensitive and resistant cell lines', S. Gurdag, J. Khandare, S. Staples, R. M. Kannan, L. Matherly, Bioconjugate Chemistry, 17, 275-283, 2005
